Molecular Hydrogen Research – Sepsis, Gastritis, Intestine

Zheng, W., et al., Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Fusarium Toxin-Contaminated Diet. Toxins (Basel), 2018. 10(6).

Xiao, H.W., et al., Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota. Exp Mol Med, 2018. 50(1): p. e433.

Nishimura, N., et al., Transplantation of High Hydrogen-Producing Microbiota Leads to Generation of Large Amounts of Colonic Hydrogen in Recipient Rats Fed High Amylose Maize Starch. Nutrients, 2018. 10(2).

Nakano, T., et al., Effect of molecular hydrogen on uterine inflammation during preterm labour. Biomed Rep, 2018. 8(5): p. 454-460.

Higashimura, Y., et al., Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice. Med Gas Res, 2018. 8(1): p. 6-11.

Franceschelli, S., et al., Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision. J Cell Mol Med, 2018. 22(5): p. 2750-2759.

Wu, M.J., et al., Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury due to intestinal intussusception in a rat model. Med Gas Res, 2017. 7(2): p. 101-106.

Shen, N.Y., et al., Hydrogen-rich water protects against in fl ammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression. World J Gastroenterol, 2017. 23(8): p. 1375-1386.

Ono, H., et al., Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. J Stroke Cerebrovasc Dis, 2017.

Zheng, Y. and D. Zhu, Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis. Oxid Med Cell Longev, 2016. 2016: p. 5806057.

Liu, L.D., et al., Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016. 15(1).

Tao, B., et al., Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation. Shock, 2015. 44(6): p. 593-600.

Shigeta, T., et al., Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. Transplantation, 2015. 99(3): p. 500-7.

Chen, H., et al., Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway. Int Immunopharmacol, 2015. 28(1): p. 643-54.

Zhang, J.Y., et al., Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol, 2014. 20(6): p. 1614-22.

Xue, J., et al., Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complementary and Alternative Medicine, 2014. 14(1): p. 81.

Xie, K., et al., Hydrogen gas presents a promising therapeutic strategy for sepsis. Biomed Res Int, 2014. 2014: p. 807635.

Sheng, Q., et al., Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats. J Pediatr Surg, 2013. 48(8): p. 1697-706.

Nishimura, N., et al., Colonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats. J Nutr, 2013. 143(12): p. 1943-9.

Li, G.M., et al., Effects of hydrogen-rich saline treatment on polymicrobial sepsis. Journal of Surgical Research, 2013. 181(2): p. 279-86.

He, J., et al., Protective effects of hydrogen-rich saline on ulcerative colitis rat model. Journal of Surgical Research, 2013(0).

Chen, H.G., et al., Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg, 2013. 11(10): p. 1060-6.

Xie, K., et al., Nrf2 is critical in the protective role of hydrogen gas against murine polymicrobial sepsis. British Journal of Anaesthesia, 2012. 108(3): p. 538-539.

Xie, K., et al., Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock, 2012. 38(6): p. 656-63.

Liu, X., et al., The protective of hydrogen on stress-induced gastric ulceration. Int Immunopharmacol, 2012. 13(2): p. 197-203.

Jin, Y., et al., Hydrogen May Be Used as a Treatment for Stress-Induced Gastric Ulceration. Hypotheses Res, 2011. 7: p. 43-47.

Buchholz, B.M., et al., Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation, 2011. 92(9): p. 985-92.

Xie, K.L., et al., Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock, 2010. 34(1): p. 90-97.

Xie, K.L., et al., [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(5): p. 454-7.

Kajiya, M., et al., Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun, 2009: p. in press.

Anami, S., K. Saegusa, and M. Nishikata, Effect of glutamine or alkaline ionized water on late diarrhea induced by irinotecan hydrochloride in Gunn rats. . Asian Journal of Pharmaceutical Sciences, 2009. 4(2): p. 96-105.

Jin, D.K., Dong-Heui ; Teng, Yung-Chien ; Xufeng, Qi ; Lee, Kyu-Jae The Effect of Mineral-induced Alkaline Reduced Water on the DSS-induced Acute inflammatory Bowel Disease Mouse Model. Korean Journal of Microscopy, 2008. 38(2): p. 81-87.

Buchholz, B.M., et al., Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant, 2008. 8(10): p. 2015-2024.

Vorobjeva, N.V., Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water. Med Hypotheses, 2005. 64(3): p. 543-6.

Naito, Y., et al., Chronic administration with electrolyzed alkaline water inhibits aspirin-induced gastric mucosal injury in rats through the inhibition of tumor necrosis factor-alpha expression. Journal of Clinical Biochemistry and Nutrition, 2002. 32: p. 69-81.

Senn, N., RECTAL INSUFFLATION OF HYDROGEN GAS AN INFALLIBLE TEST IN THE DIAGNOSIS OF VISCERAL INJURY OF THE GASTRO INTESTINAL CANAL IN PENETRATING WOUNDS OF THE ABDOMEN. Read in the Section on Surgery, at the Thirty-ninth Annual Meeting of the American Medical Association, May, 9, 1888, and illustrated by three experiments on dogs.”. JAMA: Journal of the American Medical Association, 1888. 10(25): p. 767-777.

Pilcher, J.E., Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas. Annals of Surgery, 1888. 8(3): p. 190-204.

Shin, D.W., et al., Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study. Evid Based Complement Alternat Med. 2018; doi: 10.1155/2018/9147914